Article
IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation.
Neuro-oncology - 1 Sept 2022
Mortazavi Armin, Fayed Islam, Bachani Muzna, Dowdy Tyrone, Jahanipour Jahandar, Khan Anas, Owotade Jemima, Walbridge Stuart, Inati Sara K, Steiner Joseph, Wu Jing, Gilbert Mark, Yang Chun Zhang, Larion Mioara, Maric Dragan, Ksendzovsky Alexander, Zaghloul Kareem A
Abstract excerpt
BACKGROUND: Uncontrolled seizures in patients with gliomas have a significant impact on quality of life and morbidity, yet the mechanisms through which these tumors cause seizures remain unknown. Here, we hypothesize that the active metabolite d-2-hydroxyglutarate (d-2-HG) produced by the IDH-mutant enzyme leads to metabolic disruptions in surrounding cortical neurons that consequently promote seizures. METHODS:...
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