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Article

TMEM106B Fibrils from FTLD Patients and Healthy Controls.

ACS chemical neuroscience - 16 Aug 2023

Greenwood James D, Powell Wyatt C, Walczak Maciej A

Abstract excerpt

Recent studies involving four research teams have revealed that amyloid fibrils in FTLD-TDP patients and cognitively healthy individuals primarily consist of TMEM106B, a protein previously identified as a risk factor for FTLD-TDP. Through cryogenic electron microscopy, the studies identified various protofilament structures of TMEM106B fibrils from individuals with several neurodegenerative diseases. These...

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Identifiers

PMID: 37530644
DOI: 10.1021/acschemneuro.3c00482
PMCID: PMC10528478

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