Article
Epidemiology, Outcomes, and Complement Gene Variants in Secondary Thrombotic Microangiopathies.
Clinical journal of the American Society of Nephrology : CJASN - 1 Jul 2023
Werion Alexis, Storms Pauline, Zizi Ysaline, Beguin Claire, Bernards Jelle, Cambier Jean-François, Dahan Karin, Dierickx Daan, Godefroid Nathalie, Hilbert Pascale, Lambert Catherine, Levtchenko Elena, Meyskens Thomas, Poiré Xavier, van den Heuvel Lambert, Claes Kathleen J, Morelle Johann
Abstract excerpt
BACKGROUND: The identification of complement defects as major drivers of primary atypical hemolytic uremic syndrome (HUS) has transformed the landscape of thrombotic microangiopathies (TMAs), leading to the development of targeted therapies and better patient outcomes. By contrast, little is known about the presentation, genetics, and outcomes of TMA associated with specific diseases or conditions, also referred...
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