Article
Underlying Genetics of aHUS: Which Connection with Outcome and Treatment Discontinuation?
International journal of molecular sciences - 24 Sept 2023
Spasiano Andrea, Palazzetti Daniela, Dimartino Lucrezia, Bruno Francesca, Baccaro Rocco, Pesce Francesco, Grandaliano Giuseppe
Abstract excerpt
Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by a genetic dysregulation of the alternative complement pathway, characterized by thrombocytopenia, hemolytic anemia, and acute kidney injury, and included in the group of thrombotic microangiopathies. With the introduction of humanized monoclonal antibodies that inhibit C5 activation, the natural history of aHUS completely changed, with a better...
Topics
Join the communities discussing this publication.