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Article

Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics.

Nature reviews. Nephrology - 1 Aug 2021

Fakhouri Fadi, Frémeaux-Bacchi Véronique

Abstract excerpt

Studies of complement genetics have changed the landscape of thrombotic microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS). Knowledge of complement genetics paved the way for the design of the first specific treatment for aHUS, eculizumab, and is increasingly being used to aid decisions regarding discontinuation of anti-complement treatment in this setting. Complement genetic...

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PMID: 33953366
DOI: 10.1038/s41581-021-00424-4

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