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Article

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.

Nature immunology - 1 Jun 2007

Acosta-Rodriguez Eva V, Rivino Laura, Geginat Jens, Jarrossay David, Gattorno Marco, Lanzavecchia Antonio, Sallusto Federica, Napolitani Giorgio

Abstract excerpt

Interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORgammat, a transcription factor,...

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Source

Identifiers

PMID: 17486092
DOI: 10.1038/ni1467

Genes

CCR6
CCR4
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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