Article
Identification of combinatorial mutations associated with colistin resistance in Shewanella algae.
Microbes and infection - 1 Jan 2000
Huang Yao-Ting, Mao Yan-Chiao, Tseng Chien-Hao, Liu Chia-Wei, Liu Po-Yu
Abstract excerpt
Colistin is a last-resort antibiotic used to treat infections caused by drug-resistant gram-negative bacteria. However, the genetic mechanisms underlying colistin resistance in Shewanella algae are not well understood. In this study, we sequenced and compared the genomes of 23 mcr-negative colistin-resistant and sensitive S. algae samples from various sources. We applied a computational approach to identify...
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