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Article

Generation of 2 isogenic clones from a patient with Trisomy 21 and a GATA1 mutation.

Stem cell research - 1 Jun 2023

Takasaki Kaoru, Kumar Sara S, Gagne Alyssa, French Deborah L, Chou Stella T

Abstract excerpt

Trisomy 21 (T21), or Down Syndrome (DS), is a common chromosomal disorder resulting from a third copy of chromosome 21 (HSA21). Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with DS and is characterized by a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a pair of isogenic T21 lines derived from a patient...

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Source

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Identifiers

PMID: 37084616
DOI: 10.1016/j.scr.2023.103098
PMCID: PMC10576909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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