Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of CHOPi-008-B, a euploid iPSC line from a patient with Trisomy 21 and a GATA1 mutation.

Stem cell research - 1 Oct 2023

Takasaki Kaoru, Kumar Sara S, Gagne Alyssa, French Deborah L, Chou Stella T

Abstract excerpt

Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a euploid iPSC line with a GATA1s mutation that is isogenic to a previously published pair of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to GATA1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Induced Pluripotent Stem Cells

Share to Infant, Newborn

Share to Leukemia, Megakaryoblastic, Acute

Share to Mutation

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 37677872
DOI: 10.1016/j.scr.2023.103198
PMCID: PMC10872805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of CHOPi-008-B, a euploid iPSC line from a patient with Trisomy 21 and a GATA1 mutation.PMID 37677872Read ↗

Generation of 2 isogenic clones from a patient with Trisomy 21 and a GATA1 mutation.Semantic proximity Read ↗

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.Semantic proximity Read ↗

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation.Semantic proximity Read ↗

Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research.Semantic proximity Read ↗

Single-cell transcriptomics reveal individual and synergistic effects of Trisomy 21 and GATA1s on hematopoiesisSemantic proximity Read ↗

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cellsSemantic proximity Read ↗

Transient myeloproliferative disorder in children with <scp>D</scp>own syndrome: clarity to this enigmatic disorderSemantic proximity Read ↗

iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.Semantic proximity Read ↗

Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature.Semantic proximity Read ↗

Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21.Semantic proximity Read ↗

Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesisSemantic proximity Read ↗

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.