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Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

8 Oct 2012

Abstract excerpt

Patients with Down syndrome (trisomy 21, T21) have hematologic abnormalities throughout life. Newborns frequently exhibit abnormal blood counts and a clonal preleukemia. Human T21 fetal livers contain expanded erythro-megakaryocytic precursors with enhanced proliferative capacity. The impact of T21 on the earliest stages of embryonic hematopoiesis is unknown and nearly impossible to examine in human subjects. We...

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PMID: 23045704
DOI: 10.1073/pnas.1211175109

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