Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.

Cell stem cell - 5 May 2016

McNulty Maureen, Crispino John D

Abstract excerpt

GATA1 mutations and trisomy 21 are inextricably linked in the neonatal leukemia of children with Down syndrome (DS). A recent report by Banno et al. (2016) sheds new light on the mechanism of the synergy between these genetic alterations by modeling hematopoietic abnormalities with patient-derived induced pluripotent stem cells.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to GATA1 Transcription Factor
Share to GATA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mutation

Source

Identifiers

PMID: 27152438
DOI: 10.1016/j.stem.2016.04.007

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation.PMID 27152438Read ↗

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.Semantic proximity Read ↗

Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21.Semantic proximity Read ↗

Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease.Semantic proximity Read ↗

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologiesSemantic proximity Read ↗

Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype.Semantic proximity Read ↗

Generation of 2 isogenic clones from a patient with Trisomy 21 and a GATA1 mutation.Semantic proximity Read ↗

Induced pluripotent stem cells as a cellular model for studying Down SyndromeSemantic proximity Read ↗

Evolution of myeloid leukemia in children with Down syndrome.Semantic proximity Read ↗

Molecular insights into Down syndrome-associated leukemia.Semantic proximity Read ↗

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.Semantic proximity Read ↗

Down syndrome and leukemia: from basic mechanisms to clinical advancesSemantic proximity Read ↗

Leukemogenesis in infants and young children with trisomy 21.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.