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Article

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity.

Microbiome - 20 Apr 2023

Liu Hongjiao, Ling Wodan, Hua Xing, Moon Jee-Young, Williams-Nguyen Jessica S, Zhan Xiang, Plantinga Anna M, Zhao Ni, Zhang Angela, Knight Rob, Qi Qibin, Burk Robert D, Kaplan Robert C, Wu Michael C

Abstract excerpt

BACKGROUND: Understanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics may influence health outcomes. Typical microbiome genome-wide association studies (GWAS) marginally assess the association between individual genetic variants and individual microbial taxa. We propose a novel approach, the covariate-adjusted kernel RV (KRV) framework, to map genetic variants...

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PMID: 37081571
DOI: 10.1186/s40168-023-01530-0
PMCID: PMC10116795

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