Article

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity

2021-10-16

Abstract excerpt

Understanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics affects health outcomes. We propose a novel approach, the covariate-adjusted kernel RV (KRV) framework, to map genetic variants associated with microbiome beta-diversity, which focuses on overall shifts in the microbiota. The proposed KRV framework improves statistical power by capturing intrinsic structur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b8907ad-780d-530b-93df-d6253bf2e969
DOI: 10.1101/2021.10.15.464608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversityDOI 10.1101/2021.10.15.464608Read

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity.Semantic proximity Read

Testing in Microbiome-Profiling Studies with MiRKAT, the Microbiome Regression-Based Kernel Association Test.Semantic proximity Read

MicrobiomeGWAS: a tool for identifying host genetic variants associated with microbiome compositionSemantic proximity Read

The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition.Semantic proximity Read

MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition.Semantic proximity Read

Genome-wide association study (GWAS) of host germline variation and the gut microbiome: The Multiethnic Cohort StudySemantic proximity Read

A small-sample multivariate kernel machine test for microbiome association studies.Semantic proximity Read

Challenges and future directions for studying effects of host genetics on the gut microbiome.Semantic proximity Read

Power of Microbiome Beta-Diversity Analyses Based on Standard Reference SamplesSemantic proximity Read

Environmental factors dominate over host genetics in shaping human gut microbiota compositionSemantic proximity Read

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.Semantic proximity Read

Identifying Host Genetic Variants Associated with Microbiome Composition by Testing Multiple Beta Diversity Matrices.Semantic proximity Read