Article

Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicing

2022-06-08

Abstract excerpt

Matrin3 is an RNA-binding protein that affects diverse RNA-related processes, including mRNA splicing. While Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we discovered Matrin3-mediated regulation of mitotic spindle dynamics in colorectal cancer (CRC) cells. We identified bound and regulated Matrin3-target RNAs transcriptome-wide in CRC cells and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9b5d206-1f8d-5074-9c54-66eb23dbc8b3
DOI: 10.1101/2022.06.08.495349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicingDOI 10.1101/2022.06.08.495349Read

RNA-Binding Motif Protein 3 as a Therapeutic and Prognostic Target for Drug DiscoverySemantic proximity Read

Matrin-3 promotes hepatocellular carcinoma progression by regulating cell cycleSemantic proximity Read

Oncogenic CDK13 mutations impede nuclear RNA surveillance.Semantic proximity Read

Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 StabilizationSemantic proximity Read

Role of RBMS3 Novel Potential Regulator of the EMT Phenomenon in Physiological and Pathological ProcessesSemantic proximity Read

The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.Semantic proximity Read

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networksSemantic proximity Read

MATR3’s Role beyond the Nuclear Matrix: From Gene Regulation to Its Implications in Amyotrophic Lateral Sclerosis and Other DiseasesSemantic proximity Read

SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/AKT/Notch1 signaling pathwaySemantic proximity Read

STNM1 in human cancers: role, function and potential therapy sensitizerSemantic proximity Read

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in CancersSemantic proximity Read

Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosisSemantic proximity Read