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Article

Cellular RNA surveillance in health and disease.

Science (New York, N.Y.) - 15 Nov 2019

Wolin Sandra L, Maquat Lynne E

Abstract excerpt

The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that...

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Identifiers

PMID: 31727827
DOI: 10.1126/science.aax2957
PMCID: PMC6938259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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