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Jumonji domain‐containing protein‐3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosis

20 Apr 2023

Abstract excerpt

BACKGROUND AND PURPOSE: Renal fibrosis is a common feature of chronic kidney disease. Myeloid fibroblasts and macrophages contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying myeloid fibroblast activation and macrophage polarization are not fully understood. In this study, we examined the role of Jumonji domain-containing protein-3 (JMJD3) in myeloid...

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PMID: 37076137
DOI: 10.1111/bph.16096

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