Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA

13 Sept 2018

Abstract excerpt

Renal fibrosis is a histological manifestation that occurs in almost every type of chronic kidney disease. Histone variant H3.3 and its chaperone, histone cell cycle regulation defective homolog A (HIRA), serve as epigenetic marks that regulate transcriptional activity. In this study, we assessed the roles of histone H3.3 and HIRA in unilateral ureteral-obstruction (UUO) mice. In UUO mice, the levels of histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connective Tissue Growth Factor Research
Share to Occupational and environmental lung diseases
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30232404
DOI: 10.1038/s41598-018-32518-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRAPMID 30232404Read ↗

Role of Histone Modifications in Kidney FibrosisSemantic proximity Read ↗

Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progressionSemantic proximity Read ↗

Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylationSemantic proximity Read ↗

Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal FibrosisSemantic proximity Read ↗

LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p/TGF-βR1/COL1A1 axisSemantic proximity Read ↗

Epigenetic regulation in the acute kidney injury to chronic kidney disease transitionSemantic proximity Read ↗

Jumonji domain‐containing protein‐3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosisSemantic proximity Read ↗

Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.Semantic proximity Read ↗

TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA AxisSemantic proximity Read ↗

Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro.Semantic proximity Read ↗

Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosisSemantic proximity Read ↗

Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.