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Article

The effect of antagonistic pleiotropy on the estimation of the average coefficient of dominance of deleterious mutations.

Genetics - 1 Dec 2005

Fernández B, García-Dorado A, Caballero A

Abstract excerpt

We investigate the impact of antagonistic pleiotropy on the most widely used methods of estimation of the average coefficient of dominance of deleterious mutations from segregating populations. A proportion of the deleterious mutations affecting a given studied fitness component are assumed to have an advantageous effect on another one, generating overdominance on global fitness. Using diffusion approximations...

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Identifiers

PMID: 16118193
DOI: 10.1534/genetics.105.044750
PMCID: PMC1456129

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