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A Recent Update of Pharmacogenomics in Drug-induced Severe Skin Reactions

1 Nov 2011

Abstract excerpt

In some adverse drug reactions (ADRs), genetic predisposition plays a significant role in pathogenesis, and the skin is the most frequently reported target. These severe cutaneous ADRs include bullous fixed drug eruptions (FDE), acute generalized exanthematous pustulosis (AGEP), drug-induced hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The putative...

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PMID: 22041139
DOI: 10.2133/dmpk.dmpk-11-rv-116

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