Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.

Expert review of clinical immunology - 1 Jul 2012

Ko Tai-Ming, Chen Yuan-Tsong

Abstract excerpt

Ample evidence exists to support the view that drug hypersensitivity is mediated by adaptive immunity, which involves MHC-restricted drug presentation, activation and clonal expansion of T cells. The specific MHC molecules implicated in hypersensitivity have been identified; for example, HLA-B*5701 in abacavir-induced drug hypersensitivity and HLA-B*1502 in carbamazepine-induced Stevens-Johnson syndrome. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Carbamazepine
Share to Drug Hypersensitivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HLA-B Antigens

Share to Receptors, Antigen, T-Cell

Share to Stevens-Johnson Syndrome

Source

Identifiers

PMID: 22882221
DOI: 10.1586/eci.12.31

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.PMID 22882221Read ↗

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.Semantic proximity Read ↗

T Cell–Mediated Hypersensitivity Reactions to DrugsSemantic proximity Read ↗

Characterization of Drug-Specific CD4+ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity ReactionsSemantic proximity Read ↗

Human leukocyte antigens and drug hypersensitivity.Semantic proximity Read ↗

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.Semantic proximity Read ↗

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.Semantic proximity Read ↗

Pharmacogenetics of cutaneous adverse drug reactionsSemantic proximity Read ↗

A Recent Update of Pharmacogenomics in Drug-induced Severe Skin ReactionsSemantic proximity Read ↗

Genetic associations of human leukocyte antigen alleles in cutaneous delayed drug hypersensitivity reactions: An updated reviewSemantic proximity Read ↗

Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China.Semantic proximity Read ↗

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.Semantic proximity Read ↗

HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.