Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome

19 Apr 2023

Abstract excerpt

Abstract Inflammasome signaling is a central pillar of innate immunity triggering inflammation and cell death in response to microbes and danger signals. Here, we show that two virulence factors from the human bacterial pathogen Clostridium perfringens are nonredundant activators of the NLRP3 inflammasome in mice and humans. C. perfringens lecithinase (also known as phospolipase C) and C. perfringens...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gout, Hyperuricemia, Uric Acid
Share to Inflammasome and immune disorders
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37073791
DOI: 10.15252/embr.202254600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasomePMID 37073791Read ↗

Inflammasome activation via intracellular NLRs triggered by bacterial infectionSemantic proximity Read ↗

Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensingSemantic proximity Read ↗

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasomeSemantic proximity Read ↗

NLRP3 Inflammasome and Host Protection against Bacterial InfectionSemantic proximity Read ↗

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cellsSemantic proximity Read ↗

Epithelial inflammasomes in the defense against Salmonella gut infectionSemantic proximity Read ↗

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasomeSemantic proximity Read ↗

The <i>Achromobacter</i> Type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomesSemantic proximity Read ↗

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.Semantic proximity Read ↗

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.Semantic proximity Read ↗

The role of inflammasome modulation in virulenceSemantic proximity Read ↗

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.