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Article

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.

The Journal of experimental medicine - 7 Apr 2014

Wynosky-Dolfi Meghan A, Snyder Annelise G, Philip Naomi H, Doonan Patrick J, Poffenberger Maya C, Avizonis Daina, Zwack Erin E, Riblett Amber M, Hu Baofeng, Strowig Till, Flavell Richard A, Jones Russell G, Freedman Bruce D, Brodsky Igor E

Abstract excerpt

Microbial infection triggers assembly of inflammasome complexes that promote caspase-1-dependent antimicrobial responses. Inflammasome assembly is mediated by members of the nucleotide binding domain leucine-rich repeat (NLR) protein family that respond to cytosolic bacterial products or disruption of cellular processes. Flagellin injected into host cells by invading Salmonella induces inflammasome activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24638169
DOI: 10.1084/jem.20130627
PMCID: PMC3978275

Genes

NLRP3
NLRC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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