Article

Hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

2018-03-28

Abstract excerpt

Inflammatory caspase-11/4/5 recognize cytosolic LPS from invading Gram-negative bacteria and induce pyroptosis and cytokine release, forming rapid innate antibacterial defenses. Since extracellular or vacuole-constrained bacteria are thought to rarely access the cytoplasm, how their LPS are exposed to the cytosolic sensors is a critical event for pathogen recognition. Hemolysin is a pore-forming bacterial toxin, w...

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Literature Corpus work: 87a94eca-a867-5e1a-b2ed-824cd4e6095b
DOI: 10.1101/290445

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