Article

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

2025-01-24

Abstract excerpt

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caused by sterile triggers or bacterial pathogens such as Listeria monocytogenes in human intestinal epithelial cells (IECs). NLRP6 activation required Listeriolysin O-dependent cytosolic invasion of L. monocytogenes an...

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Literature Corpus work: c23780dd-3db2-5553-aad3-fb4dddacd1c9
DOI: 10.1101/2025.01.23.634286

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