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Article

Adeno‐Associated Viral Vectors for Homology‐Directed Generation of CAR‐T Cells

23 Oct 2019

Abstract excerpt

Immunotherapy with T cells expressing chimeric antigen receptors (CAR) is an emerging and promising treatment against refractory cancers. However, the currently adopted methods of modification of T cells pose a risk of insertional oncogenesis because lentiviral and retroviral vectors integrate the CAR transgene in a semi-random fashion. In addition, this therapy is only available using autologous cells, which...

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PMID: 31642193
DOI: 10.1002/biot.201900286

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