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TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

26 Apr 2016

Abstract excerpt

Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling has fundamental roles in both embryonic skeletal development and postnatal bone homeostasis. TGF-βs and BMPs, acting on a tetrameric receptor complex, transduce signals to both the canonical Smad-dependent signaling pathway (that is, TGF-β/BMP ligands, receptors, and Smads) and the non-canonical-Smad-independent signaling pathway...

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PMID: 27563484
DOI: 10.1038/boneres.2016.9

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