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More similar than different: Host cell protein production using three null CHO cell lines

20 Apr 2015

Abstract excerpt

To understand the diversity in the cell culture harvest (i.e., feedstock) provided for downstream processing, we compared host cell protein (HCP) profiles using three Chinese Hamster Ovary (CHO) cell lines in null runs which did not generate any recombinant product. Despite differences in CHO lineage, upstream process, and culture performance, the cell lines yielded similar cell-specific productivities for...

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PMID: 25894672
DOI: 10.1002/bit.25615

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