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Article

Proteome analysis of antibody‐producing CHO cell lines with different metabolic profiles

26 Apr 2007

Abstract excerpt

Two-dimensional gel electrophoresis and tandem mass spectrometry were used to identify proteins associated with a metabolic shift during fed-batch cultures of two recombinant antibody-producing CHO cell lines. The first cell line underwent a marked change in lactate metabolism during culture, initially producing lactate and then consuming it, while the second cell line produced lactate for a similar duration but...

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PMID: 17461427
DOI: 10.1002/bit.21460

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