Article
Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells.
Journal of structural biology - 1 Jun 2023
Francia Marcos Gabriel, Oses Camila, Roberti Sabrina Lorena, García Mora Reneé, Cozza Lucas Helio, Diaz Maria Candelaria, Levi Valeria, Guberman Alejandra Sonia
Abstract excerpt
AKT/PKB is a kinase involved in the regulation of a plethora of cell processes. Particularly, in embryonic stem cells (ESCs), AKT is crucial for the maintenance of pluripotency. Although the activation of this kinase relies on its recruitment to the cellular membrane and subsequent phosphorylation, multiple other post-translational modifications (PTMs), including SUMOylation, fine-tune its activity and target...
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