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Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21<sup>Waf1/Cip1</sup>and p27<sup>kip1</sup>

2 Jun 2015

Abstract excerpt

UNLABELLED: Cancer stem-like cells (CSCs) are a rare subpopulation of cancer cells capable of propagating the disease and causing cancer recurrence. In this study, we found that the cellular localization of PKB/Akt kinase affects the maintenance of CSCs. When Akt tagged with nuclear localization signal (Akt-NLS) was overexpressed in SKBR3 and MDA-MB468 cells, these cells showed a 10-15% increase in the number of...

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PMID: 26030190
DOI: 10.1080/15384101.2015.1041692

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