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Article

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.

Oncogene - 17 Apr 2014

Xie X, Piao L, Cavey G S, Old M, Teknos T N, Mapp A K, Pan Q

Abstract excerpt

Emerging evidence indicates that Nanog is intimately involved in tumorigenesis, in part, through regulation of the cancer-initiating cell (CIC) population. However, the regulation and role of Nanog in tumorigenesis are still poorly understood. In this study, human Nanog was identified to be phosphorylated by human protein kinase Cɛ at multiple residues, including T200 and T280. Our work indicated that...

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Source

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Identifiers

PMID: 23708658
DOI: 10.1038/onc.2013.173
PMCID: PMC3912208

Genes

CIC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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