Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.

doi:10.1038/onc.2013.173

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Article

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.

Oncogene - 17 Apr 2014

Xie X, Piao L, Cavey G S, Old M, Teknos T N, Mapp A K, Pan Q

Abstract excerpt

Emerging evidence indicates that Nanog is intimately involved in tumorigenesis, in part, through regulation of the cancer-initiating cell (CIC) population. However, the regulation and role of Nanog in tumorigenesis are still poorly understood. In this study, human Nanog was identified to be phosphorylated by human protein kinase Cɛ at multiple residues, including T200 and T280. Our work indicated that...

Topics

Animals
Base Sequence
Binding Sites
Carcinoma, Squamous Cell
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic
Gene Expression Regulation, Neoplastic
HEK293 Cells
Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Humans

Immunoblotting

Mass Spectrometry

Mice

Mice, Nude

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 23708658
DOI: 10.1038/onc.2013.173
PMCID: PMC3912208

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