Article
Oct4 resetting by Aurkb-PP1 cell cycle axis determines the identity of mouse embryonic stem cells.
BMB reports - 1 Oct 2016
Shin Jihoon, Youn Hong-Duk
Abstract excerpt
In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell cycle progression. Here, we describe that the regulation of Oct4 by Aurora kinase b...
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