Article
Phosphorylation stabilizes Nanog by promoting its interaction with Pin1.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010
Moretto-Zita Matteo, Jin Hua, Shen Zhouxin, Zhao Tongbiao, Briggs Steven P, Xu Yang
Abstract excerpt
Embryonic stem cells (ESCs) can undergo unlimited self-renewal and retain the pluripotency to differentiate into all cell types in the body, thus holding great promise as a renewable source of cells for human therapy. The mechanisms that maintain self-renewal of ESCs remain unclear. Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Binding Sites
- Blotting, Western
- Cell Line
- Cells, Cultured
- Embryonic Stem Cells
- Enzyme Inhibitors
- Homeodomain Proteins
- Humans