Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study.

doi:10.1093/jjco/hyad028

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Article

Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study.

Japanese journal of clinical oncology - 29 Jun 2023

Sugimoto Yukihiro, Koyanagi Yuriko N, Kawakatsu Yukino, Oze Isao, Taniyama Yukari, Kasugai Yumiko, Tanaka Tsutomu, Abe Tetsuya, Tajika Masahiro, Shimizu Yasuhiro, Ito Hidemi, Wakai Kenji, Matsuo Keitaro

Abstract excerpt

BACKGROUND: Ingested alcohol is predominantly oxidized to acetaldehyde by alcohol dehydrogenase 1B (ADH1B), and acetaldehyde is further oxidized to acetate mainly by aldehyde dehydrogenase 2 (ALDH2). Although alcohol consumption is a convincing risk factor for oesophageal cancer, the role of ADH1B rs1229984 (His48Arg), the single-nucleotide polymorphism associated with slow alcohol metabolism, in oesophageal...

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PMID: 37057635
DOI: 10.1093/jjco/hyad028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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