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Article

New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis: Evaluation by mediation analysis.

Cancer science - 1 Apr 2022

Koyanagi Yuriko N, Oze Isao, Kasugai Yumiko, Kawakatsu Yukino, Taniyama Yukari, Hara Kazuo, Shimizu Yasuhiro, Imoto Issei, Ito Hidemi, Matsuo Keitaro

Abstract excerpt

A functional variant on ALDH2 rs671 (G>A) confers a protective effect against alcohol-induced carcinogenesis through an indirect pathway mediated by decreased alcohol consumption. Conversely, this variant also contributes to the accumulation of carcinogenic agents, resulting in a direct carcinogenic effect. This study aimed to separately quantify these two opposing effects of the rs671 A allele on pancreatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcohol Drinking
Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Carcinogenesis
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Source

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Identifiers

PMID: 35102643
DOI: 10.1111/cas.15286
PMCID: PMC8990728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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