Article
The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.
Structure (London, England : 1993) - 7 Oct 2014
Kamajaya Aron, Kaiser Jens T, Lee Jonas, Reid Michelle, Rees Douglas C
Abstract excerpt
Piezo has recently been identified as a family of eukaryotic mechanosensitive channels composed of subunits containing over 2,000 amino acids, without recognizable sequence similarity to other channels. Here, we present the crystal structure of a large, conserved extramembrane domain located just before the last predicted transmembrane helix of C. elegans PIEZO, which adopts a topologically distinct β sandwich...
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