Article
Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.
Human molecular genetics - 1 Apr 2003
Hurle Belen, Ignatova Elena, Massironi Silvia M, Mashimo Tomoji, Rios Xavier, Thalmann Isolde, Thalmann Ruediger, Ornitz David M
Abstract excerpt
Otoconia are biominerals within the utricle and saccule of the inner ear that are critical for the perception of gravity and linear acceleration. The classical mouse mutant tilted (tlt) and a new allele, mergulhador (mlh), are recessive mutations that affect balance by impairing otoconial morphogenesis without causing collateral deafness. The mechanisms governing otoconial biosynthesis are not known. Here we show...
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