The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury.

doi:10.1016/j.trsl.2020.11.008

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Article

The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury.

Translational research : the journal of laboratory and clinical medicine - 1 May 2021

Malaquias Mineia Alessandra Scaranello, Gadotti Ana Carolina, Motta-Junior Jarbas da Silva, Martins Ana Paula Camargo, Azevedo Marina Luise Viola, Benevides Ana Paula Kubaski, Cézar-Neto Plínio, Panini do Carmo Letícia Arianne, Zeni Rafaela Chiuco, Raboni Sonia Mara, Fonseca Aline Simoneti, Machado-Souza Cleber, Moreno-Amaral Andrea Novais, de Noronha Lucia

Abstract excerpt

Although some evidence showed the activation of complement systems in COVID-19 patients, proinflammatory status and lectin pathway remain unclear. Thus, the present study aimed to demonstrate the role of MBL and ficolin-3 in the complement system activation and compared to pandemic Influenza A virus H1N1 subtype infection (H1N1pdm09) and control patients. A total of 27 lungs formalin-fixed paraffin-embedded...

Topics

Adult
Aged
Aged, 80 and over
Autopsy
COVID-19
Case-Control Studies
Complement Activation
Cytokines
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Immunohistochemistry

Influenza A Virus, H1N1 Subtype

Influenza, Human

Lectins

Lung

Lung Injury

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 33221483
DOI: 10.1016/j.trsl.2020.11.008
PMCID: PMC7677075

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