Article
Pivotal epitopes for islet antigen-specific CD8+ T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele.
Immunologic research - 26 Mar 2025
Chen Yang, Shen Min, Gu Yong, Xu Xinyu, Bian Lingling, Yang Fan, Chen Shuang, Ji Li, Liu Jin, Zhu Jing, Zhang Zheng, Fu Qi, Cai Yun, Chen Heng, Xu Kuanfeng, Sun Min, Zheng Xuqin, Shen Jie, Zhou Hongwen, Zhang Mei, Haskins Kathryn, Yu Liping, Yang Tao, Shi Yun
Abstract excerpt
A proportion of patients with new-onset diabetes share similar symptoms with type 1 diabetes (T1D) patients but they are negative for islet antigen-specific autoantibodies. This study was to develop an islet antigen-specific CD8+ T-cell assay to provide autoimmune evidence regarding these "suspected" T1D patients. HLA-A*0201 individuals with autoAbs+ T1D, autoAbs- suspected T1D, and type 2 diabetes, along with...
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