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Article

In Silico Optimization of GAD65114-122 Autoantigen for Potential Type 1 Diabetes Antigen-Specific Immunotherapy.

The journal of physical chemistry. B - 18 Dec 2025

Fu Lei, Chan Kevin Chun, Zhong Qinglu, Buratto Damiano, Wu Song, Zhou Ruhong

Abstract excerpt

Type 1 diabetes (T1D) is mediated by autoreactive T cells targeting pancreatic β-cell antigens, with CD8+ T cells specific for islet autoantigens playing a central role. CD8+ T cell reactivity to glutamic acid decarboxylase 65 (GAD65) in HLA-A*02:01 individuals has been reported to focus on the immunogenic region around residues 114-122 (VMNILLQYV). Here, we design GAD65114-122 mimotopes with enhanced human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41362047
DOI: 10.1021/acs.jpcb.5c04875

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