Article
Online Service with Automated Interpretation of Sequencing Data and Prediction of Pyrazinamide Resistance in Mycobacterium tuberculosis.
Bulletin of experimental biology and medicine - 1 Mar 2023
Sinkov V V, Kondratov I G, Ogarkov O B, Zhdanova S N, Sokolnikova N A, Khromova P A, Orlova E A, Rychkova L V, Kolesnikova L I
Abstract excerpt
Pyrazinamide plays an important role in the treatment of tuberculosis. However, the microbiological test for pyrazinamide resistance is more complex and less reliable than testing of susceptibility to other anti-tuberculosis drugs due to the need to grow the pathogen at pH 5.5. Identification of mutations that cause resistance to anti-tuberculosis drugs can replace microbiological methods. Mutations in the pncA...
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