Article
The role of native cysteine residues in the oligomerization of KCNQ1 channels.
Biochemical and biophysical research communications - 4 Jun 2023
Bates Alison, Stowe Rebecca B, Travis Elizabeth M, Cook Lauryn E, Dabney-Smith Carole, Lorigan Gary A
Abstract excerpt
KCNQ1, the major component of the slow-delayed rectifier potassium channel, is responsible for repolarization of cardiac action potential. Mutations in this channel can lead to a variety of diseases, most notably long QT syndrome. It is currently unknown how many of these mutations change channel function and structure on a molecular level. Since tetramerization is key to proper function and structure of the...
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