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Article

A structural requirement for processing the cardiac K+ channel KCNQ1.

The Journal of biological chemistry - 6 Aug 2004

Kanki Hideaki, Kupershmidt Sabina, Yang Tao, Wells Sam, Roden Dan M

Abstract excerpt

Normal membrane protein function requires trafficking from the endoplasmic reticulum. Here, we studied processing of the KCNQ1 channel mutated in LQT1, the commonest form of the long QT syndrome. Serial C terminus truncations identified a small region (amino acids (aa) 610-620) required for normal cell surface expression. Non-trafficked truncations assembled as tetramers but were nevertheless retained in the...

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Source

Identifiers

PMID: 15140888
DOI: 10.1074/jbc.M404539200

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A structural requirement for processing the cardiac K+ channel KCNQ1.PMID 15140888Read ↗

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