Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2012

Brast Sabine, Grabner Alexander, Sucic Sonja, Sitte Harald H, Hermann Edwin, Pavenstädt Hermann, Schlatter Eberhard, Ciarimboli Giuliano

Abstract excerpt

Human organic cation transporter 2 (hOCT2) is involved in transport of many endogenous and exogenous organic cations, mainly in kidney and brain cells. Because the quaternary structure of transmembrane proteins plays an essential role for their cellular trafficking and function, we investigated whether hOCT2 forms oligomeric complexes, and if so, which part of the transporter is involved in the oligomerization. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorescence Resonance Energy Transfer
Share to Kidney Tubules, Proximal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to Organic Cation Transport Proteins

Share to Organic Cation Transporter 2

Share to Pyridinium Compounds

Share to Tissue Culture Techniques

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 22085643
DOI: 10.1096/fj.11-180679
PMCID: PMC4503226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.PMID 22085643Read ↗

Functional significance of conserved cysteines in the human organic cation transporter 2.Semantic proximity Read ↗

Role of cysteines in mammalian VDAC isoforms' function.Semantic proximity Read ↗

Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1.Semantic proximity Read ↗

The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.Semantic proximity Read ↗

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.Semantic proximity Read ↗

Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein.Semantic proximity Read ↗

Modulation of human mitochondrial voltage-dependent anion channel 2 (hVDAC-2) structural stability by cysteine-assisted barrel-lipid interactions.Semantic proximity Read ↗

Inhibition of human NTPDase 2 by modification of an intramembrane cysteine by p-chloromercuriphenylsulfonate and oxidative cross-linking of the transmembrane domains.Semantic proximity Read ↗

Ligand-induced movements of inner transmembrane helices of Glut1 revealed by chemical cross-linking of di-cysteine mutants.Semantic proximity Read ↗

Disulfide Bonds of Thyroid Peroxidase Are Critical Elements for Subcellular Localization, Proteasome-Dependent Degradation, and Enzyme Activity.Semantic proximity Read ↗

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hcSemantic proximity Read ↗

Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.