Article
Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection.
Stem cell reports - 13 Oct 2020
Sumer Simon Alexander, Hoffmann Sandra, Laue Svenja, Campbell Birgit, Raedecke Kristin, Frajs Viktoria, Clauss Sebastian, Kääb Stefan, Janssen Johannes W G, Jauch Anna, Laugwitz Karl-Ludwig, Dorn Tatjana, Moretti Alessandra, Rappold Gudrun A
Abstract excerpt
Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation (AF), however, precise correction of the associated mutation is crucial. Here, we generated and corrected hiPSC lines from two AF patients carrying different heterozygous...
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