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Generation of one human induced pluripotent stem cell line (XACHi004-A) with heterozygous mutation of RYR2 gene from an atrial fibrillation patient.

Stem cell research - 1 Dec 2022

Zhou Yafei, Jiang Congshan, Wang Jie, Huang Wenjun, Zhang Yanmin, Zhou Rui

Abstract excerpt

As the most frequently diagnosed arrhythmia, atrial fibrillation (AF) has been recently reported to be closely related to ryanodine receptor (RyR2) dysfunction and calcium leak. Here, using non-integrating sendai viral method, we generated one iPSC line from peripheral blood mononuclear cells (PBMC) isolated a 10-year-old boy with simple atrial fibrillation which carries the heterozygous mutation in RYR2 gene...

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PMID: 36335801
DOI: 10.1016/j.scr.2022.102955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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