Article
Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies.
Nature biomedical engineering - 1 Nov 2023
Soteriou Despina, Kubánková Markéta, Schweitzer Christine, López-Posadas Rocío, Pradhan Rashmita, Thoma Oana-Maria, Györfi Andrea-Hermina, Matei Alexandru-Emil, Waldner Maximilian, Distler Jörg H W, Scheuermann Stefan, Langejürgen Jens, Eckstein Markus, Schneider-Stock Regine, Atreya Raja, Neurath Markus F, Hartmann Arndt, Guck Jochen
Abstract excerpt
During surgery, rapid and accurate histopathological diagnosis is essential for clinical decision making. Yet the prevalent method of intra-operative consultation pathology is intensive in time, labour and costs, and requires the expertise of trained pathologists. Here we show that biopsy samples can be analysed within 30 min by sequentially assessing the physical phenotypes of singularized suspended cells...
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