Article
Multiparameter mechanical and morphometric screening of cells.
Scientific reports - 2 Dec 2016
Masaeli Mahdokht, Gupta Dewal, O'Byrne Sean, Tse Henry T K, Gossett Daniel R, Tseng Peter, Utada Andrew S, Jung Hea-Jin, Young Stephen, Clark Amander T, Di Carlo Dino
Abstract excerpt
We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply machine-learning approaches to discriminate different cell types and states. When employing the full 15 dimensional dataset, the technique robustly classifies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.