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Article

A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling.

PloS one - 1 Jan 2023

Khatib Tala O, Amanso Angelica M, Knippler Christina M, Pedro Brian, Summerbell Emily R, Zohbi Najdat M, Konen Jessica M, Mouw Janna K, Marcus Adam I

Abstract excerpt

Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized our understanding of heterogeneity, in isolation they cannot correlate phenotypic information within a physiologically relevant live-cell state with molecular...

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PMID: 37819930
DOI: 10.1371/journal.pone.0292554
PMCID: PMC10566726

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