Article

TissueGrinder, a novel technology for rapid generation of patient-derived single cell suspensions from solid tumors by mechanical tissue dissociation

2021-06-08

Abstract excerpt

<h4>Introduction</h4> Recent advances hold promise of making personalized medicine a step closer to implementation in clinical settings. However, traditional sample preparation methods are not robust and reproducible. In this study, the TissueGrinder, a novel mechanical semi-automated benchtop device, which can isolate cells from tissue in a very fast and enzyme-free way is tested for cell isolation from surgical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50e3127f-b810-595f-9329-d4f6dd9a10f7
DOI: 10.1101/2021.06.08.447529

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TissueGrinder, a novel technology for rapid generation of patient-derived single cell suspensions from solid tumors by mechanical tissue dissociationDOI 10.1101/2021.06.08.447529Read

Novel microfluidic platform accelerates processing of tissue into single cells for molecular analysis and primary culture modelsSemantic proximity Read

Rapid and non-enzymatic in vitro retrieval of tumour cells from surgical specimens.Semantic proximity Read

Factors Affecting Cell Viability during the Enzymatic Dissociation of Human Endocrine Tumor TissuesSemantic proximity Read

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenograftsSemantic proximity Read

Genome-wide transcriptome profiling of ex-vivo precision-cut slices from human pancreatic ductal adenocarcinomaSemantic proximity Read

Transcriptome Profiling of Panc-1 Spheroid Cells with Pancreatic Cancer Stem Cells Properties Cultured by a Novel 3D Semi-Solid SystemSemantic proximity Read

Standardized GMP-compliant scalable production of human pancreas organoidsSemantic proximity Read

Laser Capture Microdissection: A Gear for Pancreatic Cancer ResearchSemantic proximity Read

An automation workflow for high-throughput manufacturing and analysis of scaffold-supported 3D tissue arraysSemantic proximity Read

Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestineSemantic proximity Read

3D culture of pancreatic cancer cells <i>in vitro</i> recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed <i>in vivo</i>Semantic proximity Read

Microfluidic device for primary tumor spheroid isolationSemantic proximity Read